All of the main VAs from the Yu-Gi-Oh! Original, Duelist, GX, 5D's, ZEXAL Manga Dubs reprises their roles with the exceptions of:

- Squeakychiona voices Akiza Izinski in place of Krysdolly.

- CrowBaby voices Reginald “Shark” Kastle in place of Jyran.

Also featuring:

- BloodyPikachuuu as Mizar / Specter

- GamesCage as George Jersey

- Rarityfangirl as Asana Mutsuba