Juzo is rough and prone to violence when he loses his short temper. He has a harsh way of speaking and he is accustomed to bullying others to get his point across. He is rather serious, with many of his smiles being mocking rather than genuine. He is described by Misaki Asano as "the most aggressive person in Future Foundation." People who work underneath him in the 6th Division are constantly fearful when he is around. However, he can restrain himself and become serious when needed. In Danganronpa Gaiden, he is shown to be calculating and carefulーdevising an undercover operation in order to confront Killer Killer. He is also resourceful during the Final Killing Game, making use of his environment to create weapons, like an office chair or a pipe, to avoid triggering his own NG Code.

In his official profile, it's stated that Juzo is often misunderstood due to his appearance and behavior, and only a few understand his true intentions. Despite his harshness, he is described as a good guy in the end. He hates people who care more about protecting themselves than protecting others—which is shown by his disgust at Hope's Peak's actions trying to cover up Natsumi and Sato's murders to preserve their reputation. He also cares very much about his friends; he is incredibly loyal to Kyosuke, described as willing to "dirty his hands without regret" for him. He is mostly seen smiling, joking and generally showing a more softer side in Kyosuke's company. He values Kyosuke's life and opinions over his own, being very determined to support him in every situation. Being seen as useful to Kyosuke is the one thing that seems to make him happiest and in general he seems to relax in his presence. He is also close with Chisa Yukizome and treats her as an equal, with genuine warmth like he does with Kyosuke, though being a serious person himself he is consistently annoyed with how carried away she could get.