Squigly is one of the main protagonists in Skullgirls and one of the supporting protagonists in this game! Fourteen years ago, tragedy befell Squigly’s family when the Medici Mafia came close to obtaining the Skull Heart. Lorenzo's top assassin, Black Dahlia, was ordered to murder Squigly and her parents by the Mafia - the very people who seemed to be some of their family's closest allies. It was during this incident that her mother had made the wish to bring back all the Contiellos back to life, becoming the Skullgirl. Squigly would have been one of her minions if her father did not have Leviathan bond with Squigly as his new host. Going to Medici Tower, she then met Annie, Big Band, Panzerfaust and Deep Violet. She reluctantly agreed to help fight her parents. Upon succeeding, she and Leviathan "died" once more due to the Skullgirl being gone. Big Band and Panzerfaust both agreed to keep the tale of what Squigly did secret. Lorenzo organized and attended the funeral of the Contiellos himself, but it was during this time that he stitched Squigly's mouth together, in an attempt to hide his role in the fall of her family. Fast forward to this game, she and Leviathan have awakened once more, but with the Skull Heart destroyed, who could've revived them again? After crossing paths with the strangest looking creature she laid eyes on, a blue hedgehog with red shoes. She was about to find out, in the most bizarre way possible.

Her voice is and polite and speaks in proper English, she's very kind hearted and caring towards her allies, even to her foes she shows politeness and even when she defeats them, she still shows good sportsmanship making her foes leave with their heads scratching.