In Splatoon 2 Callie's disappearance at the same time as the Great Zapfish's alerts Marie to the return of DJ Octavio, leading to the recruitment of Agent 4. As the new agent makes their way through Octo Canyon, Marie begins receiving peculiar radio messages that are later revealed to be coming from Callie. When Agent 4 and Marie finally discover Callie, they learn that she has fallen under the influence of DJ Octavio's "hypnoshades" and is now working as one of his subordinates. During the following battle, Marie manages to shoot off the hypnoshades with her Hero Charger, bringing Callie back to her senses.