In spite of her serious illness, Angelica has a rather chipper, bubbly personality. Being young, she acts absent-minded and spacey, noted when Sale arrives at the Narcotic Team's warehouse and Angelica doesn't appear to notice him. However, Angelica is actually fairly observant of others and their abilities, such as Mario Zucchero and his Stand, Soft Machine.

She seems to take amusement in others' misfortune, such as laughing hysterically during Massimo Volpe's rough treatment of Vittorio Cataldi. She also has no qualms with intense violence, and will pull an entire town into a life-threatening situation if she feels she has to.

Commonly referred to as a "junkie girl", Angelica is severely addicted to the drugs of the Narcotics Team, especially those Massimo develops for her with Manic Depression in order to alleviate the pain and progression of her illness.

Angelica is very fond of her teammates, and tends to drape herself onto them. She ecstatically greets Vladimir Kocaqi upon his return to the group, and kisses Vittorio on his face in order to encourage him during one of their final confrontations. She shows particular faith in Vittorio's strength in battle, sounding motherly to him. However, due to her dependency on Manic Depression, she shares a special fondness for Massimo. Bothered by his apathetic personality, she encourages him to make real, genuine smiles, even pulling the corners of his mouth to make him smile. Before her death, her final words to him praise him on his genuine smile.

After Kocaqi's death, Angelica becomes extremely unstable. She sobs and mourns him in the warehouse, Vittorio unable to comfort her. However, after a particularly loud sob of anguish and anger, she declares that they must make Fugo, Sheila E, and Cannolo Murolo pay for Kocaqi's murder.