He has a serious and stubborn personality, while being careful about everything he does. His supports with Kiragi show that he is often concerned with his father's actions around Kiragi's father, believing that such actions are "deplorable".

As it turns out, Hinata's issues with women passed onto Hisame, just in a different way; Hinata is incredibly gullible with women, whereas Hisame often has difficulty talking with them.

Hisame enjoys pickles and makes them himself, which seems to be the basis for most of his support conversations. Additionally, his obsession of them goes to the extent that if anyone degrades pickles- as shown in his C Support with Selkie-he becomes rather defensive about it to the point he tries persuading the person to like them. In his B support with the avatar, it's revealed he has a love for pickles because his father hates them. His supports with Selkie show that he keeps a years' worth of pickled food in his tent.

It is revealed in Hisame's supports with his father that Hinata named his sword, Hisamaru, in honor of Hisame. In his supports with Velouria, it reveals that he is creeped out by bugs. Hisame also likes bonsai trees, as shown in his supports with Ophelia.