The Black Hand were elite soldiers from the Brotherhood of Nod's Black Hand. They served as the Brotherhood's shock troops during the Third Tiberium War and the conflicts that led to it.

The Black Hand was originally founded as a form of religious police tasked with enforcing adherence to the teachings of Kane. However, the cult later grew to become a powerful and influential religious group that operated mostly in secret. This changed after the Second Tiberium War, when Kane disappeared. A high-ranking member of the Black Hand, Anton Slavik, rose to power within the Brotherhood and revealed himself as a Black Hand prelate.