Misao is the tragic heroine and titular character of the game. She is noted throughout the game as being friendless and lonely. Misao went "missing" three months before the game began.

At the beginning, the only known information regarding Misao is that she had mysteriously vanished three months before the game, with many of her classmates believing that Misao was already dead. In addition to that, a conversation overheard by the player from other classmates (Tohma, Yoshino, Saotome, and Kudoh) reveals that she may have had a crush on Tohma and was bullied by Yoshino before her disappearance. After, several strange paranormal events began and it's discussed amongst the others that these may have been Misao's doing. When Tohma jokingly and mockingly asks Misao to 'spare' him from her wrath, Misao unleashes a true curse and sends the school, and everyone in it, spiraling into an otherworldly realm filled with terrifying monsters and ghosts.

Misao originally contacts the player through their dreams and minds, asking them to "help" and "find her". When she enacts the curse, the player is the only one who can still hear her voice, continually pressing the character to find her.