The Madarai Brothers (斑井兄弟 Madarai kyōdai) are characters featured in Danganronpa/Zero.

Though originally assumed to be just a one man named Isshiki Madarai (斑井 一式) with the title Ultimate Bodyguard (超高校級の「ボディーガード」chō kōkō kyū no “bodīgādo” lit. Super High School Level Bodyguard), it is later revealed that there is actually eight identical siblings including Isshiki, Nisshiki (二式), Misshiki (三式), Yosshiki (四式), Sasshiki (五式), Rosshiki (六式), Shisshiki (七式) and Yasshiki (八式). With superhuman synchronization skills, they pose as one, their true shared talent being the Ultimate Multiple Birth Siblings (超高校級の「多胎児」chō kōkō kyū no “tataiji” lit. Super High School Level Multiple Birth Siblings).

They are mentioned to be members of Hope's Peak Academy's Student Council, however, it seems they are mostly just considered the council's bodyguards. They weren't even targets for The Tragedy of Hope's Peak Academy, which they just consider humiliating, because they were not given a chance to utilize their talent. They are portrayed as cautious and vigilant, looking for revenge for themselves and the student council.

Though not all of them were seen getting killed directly, all of the brothers were murdered by Mukuro Ikusaba.

The Madarai brothers appear in the 30-minutes long OVA, Super Danganronpa 2.5: Nagito Komaeda and the Destroyer of the World as a part of Nagito Komaeda's imagination world.