Natsumi Kuzuryu (九頭龍 菜摘 Kuzuryū Natsumi) was the late younger sister of Fuyuhiko Kuzuryu and a minor character in Danganronpa 2: Goodbye Despair. She also made an appearance in Danganronpa 3: The End of Hope's Peak Academy - Side: Despair.

She was a student part of Hope's Peak Academy's Reserve Course. Her title, Ultimate Little Sister (超高校級の「妹」chō kōkō kyū no “imōto”), was a self-proclaimed title, solely due to her brother being the Ultimate Yakuza, but it is recognized by Fuyuhiko as revealed in one of his Free Time Events.

She was killed by a fellow student named Sato, who covered it up along with Mahiru Koizumi, blaming it on a fake serial pervert. Her death was avenged by Fuyuhiko, who killed Sato in the same way that she killed his sister. This accident was revealed in Monokuma's second motive, Twilight Syndrome Murder Case.