Chisa is brave and hard-working, with a cheerful disposition. She can be dense at times, and is described by Juzo Sakakura to be "easily absorbed" by things, to the point where she loses sight of her original goal. Because of her demeanor, she plays a role in keeping the atmosphere surrounding Future Foundation as relaxed as possible.

Much like Juzo, she is very devoted to her classmate, Kyosuke Munakata, and does not regret anything he asks her to do. Chisa also has a very strong sense of right and wrong, and frequently protests Juzo's violent nature. Despite this, the two are close.

As a teacher, she is shown to be very passionate and engaging. She is able to adjust her personality to best communicate with each student—such as being kind to Mikan Tsumiki and abrasive with Fuyuhiko Kuzuryu. She is willing to go to great lengths to teach and uses certain triggers to lure out the other students, such as using Sonia Nevermind to lure Teruteru Hanamura from the kitchen of the cafeteria. She values interpersonal relationships, youth, and believes that there is more to life that just talent.

After she was brainwashed by Junko and Mukuro, Chisa fell into despair and lost all of her hope, even forgetting her feelings for Kyosuke. As a spy for Ultimate Despair, Chisa acted normally and could manipulate her own emotions; in Future Arc #10, she faked her tears after she and Kyosuke found dead bodies of kids; despite having personally murdered them in a fit of despair, Chisa put on a perfectly convincing performance of horrified sorrow as she wondered who could have done this.

At first, it seems that Chisa kept her despair persona even after her death, as she is seen watching the Final Killing Game progress while calmly eating popcorn in the afterlife, and even seems sarcastic when talking of her own death. However, in a conversation with Junko in the afterlife, Chisa rebutts Junko's claims that the world will fall into despair, stating that the world is not done for, as hope now begins. This proves that the brainwashing wore off once Chisa died, but it's unsure whether she reverted back to her original personality.