Jane Fawkeholm is the main protagonist of Fragment. A testing manager for Control Group MK40, a scientific group apart of The Ink Authority, she is ordered to a closed off base known as Otdel. Within, with the mission to find a supply of chemicals necessary for further testing in MK40, Jane discovers an abundance of corrupted, innocent test subjects, all infected with the viral Compound K, a chemical outlawed due to how easily it spreads. Now with dark secrets uncovered and a viral disease ready to seal her fate, Jane must help those not yet infected and reveal Otdel's secrets to her peers and higher-ups.

Jane is a kind and well-meaning soul, wanting nothing more than to be the best, unaware that that comes with a heavy price. Amidst her journey throughout the Otdel base, her sense of pessimism is more evident.