The Chameleon (Dmitri Smerdyakov; Russian: Дмитрий Смердяков) is a supervillain appearing in American comic books published by Marvel Comics. He is the first ever adversary of the superhero Spider-Man, having debuted in the initial issue of The Amazing Spider-Man (March 1963). The character is usually depicted as a master of disguises, known for his ability to impersonate virtually anybody. He is also the half-brother of Kraven the Hunter.

The character has appeared in several Spider-Man media adaptations over the years, including animated television series and video games. Dimitri Smerdyakov appeared in the Marvel Cinematic Universe film Spider-Man: Far From Home (2019), portrayed by Numan Acar.

IGN ranked the Chameleon as Spider-Man's 14th greatest enemy.