Set in a post apocalyptic world where the Earth is barren and the strong survive by preying on the weak, the series follows the journey of Kenshiro, the 64th successor of Hokuto Shin Ken  an ancient 1,800 year-old secret martial arts style that allows its practitioner to destroy an opponent's body from within by striking into their secret channeling points, often resulting in a violent and gruesome death. Kenshiro uses his skills to protect the weak and innocent against the numerous villains that threaten their survival.