Megumi was a kind, patient young woman, who cared more for her students than herself. She had a soft tone in her voice and generally a calm demeanor when around others. Despite being an adult, she was also very innocent and meek at times, and Yuki stated that she didn't have much of a presence. She was often ignored by the girls, though she was deeply loved and appreciated by them for her altruistic actions.

However, when she's alone, Megumi could be seen breaking down[2]. As the only surviving adult, she took it upon herself to protect her students and ensure their safety no matter the cost. She was well-liked by her students for being gentle, supportive and polite. She always wanted to help her students and comfort them, as shown by what she did for Yuki and Kurumi. In the end, Megumi was a very brave character and demonstrated a large amount of responsibility. She tended to be mature, calm, and collected when the situation called for it. She was aware of Yuki's delusions and concluded that it was her fault that "Yuki's time has stopped"[3]. She always thought positively, and she wanted to believe that help would eventually come. She wanted Yuki, Kurumi and Yuuri to leave the school with smiles on their faces.

Even after infection, she retained some of her responsibility as the students' teacher. Though she could not stop herself from attacking others, it can be seen through her scribbled journal that she still remembers them (in the anime, she wrote the names of the students in a journal kept somewhere in the basement). Rather than going to a place that was important to her, she forced herself to hide in the basement so as to minimize the chances of attacking the girls,[4] thus showing how deeply she cared for her students.