Pow-Pow is Jinx's custom-made minigun with an AI determined to cause the maximum amount of destruction possible, even if it means potential harm to Jinx. Obviously, though, it doesn't actually mean harm on anyone or anything. 

Because it's just a gun. Guns don't kill people, Jinx does.

Like with Fishbones, Pow-Pow can be either male or female as long as the voice itself can be made slightly robotic, so actors with any kind of voice are welcome to audition.